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On the other hand, strict glucose control does not limit or improve the damage caused by diabetes and its comorbidities to the CNS [17, 18] as the impact of insulin resistance, obesity, and diabetes on the CNS begins very early in the natural history of the disease [19]

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Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature

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